| 发明名称 | Methods and compositions inhibiting tumor cell proliferation | ||
| 摘要 | The invention provides agents, compositions, pharmaceutical compositions and method for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. | ||
| 申请公布号 | US8906860(B2) | 申请公布日期 | 2014.12.09 |
| 申请号 | US201313840092 | 申请日期 | 2013.03.15 |
| 申请人 | The Board of Trustees of the University of Illinois | 发明人 | Raychaudhuri Pradip;Lyubimov Alexander V.;Wang Zebin;Costa Robert |
| 分类号 | A61K38/00;C07K14/47;A61K38/17 | 主分类号 | A61K38/00 |
| 代理机构 | McDonnell Boehnen Hulbert & Berghoff LLP | 代理人 | McDonnell Boehnen Hulbert & Berghoff LLP |
| 主权项 | 1. A method of eliminating a liver cancer stem cell comprising the step of contacting the liver cancer stem cell with a polypeptide comprising (1) a p19Arf peptide fragment comprising amino acid residues KFVRSRRRPTASCALAFVN (SEQ ID NO: 16), and (2) an HIV Tat peptide of SEQ ID NO:17 or a nine-D-Arg peptide of SEQ ID NO:18 that is covalently linked to the N-terminus of the p19Arf peptide fragment, wherein the polypeptide is modified at both the N terminus and the C terminus, wherein the N terminus is modified by acetylation and wherein the C terminus is modified by amidation. | ||
| 地址 | Urbana IL US | ||