Artificial bone material having controlled calcium ion elution

摘要

Disclosed is an artificial bone material having controlled calcium ion elution, which does not induce cytotoxicity or any inflammatory response. It is found that the elution of a calcium ion from an artificial bone material for transplantation which contains a calcium-containing substance can be prevented effectively by subjecting the carrier to a surface treatment or adding a surface-treating agent to the carrier. It is also found that the induction of cytotoxicity can be prevented and the induction of an inflammatory response can also be prevented by using the above-mentioned carrier having controlled calcium ion elution.

主权项

1. A method for producing sintered artificial bone material having controlled calcium ion elution, comprising a step of washing a sintered artificial bone material which comprises a calcium-based material, with a chelating agent to remove the calcium ion that will leave from a surface of the artificial bone material when the artificial bone material is implanted in a body,
wherein the sintered artificial bone material thereby produced has controlled calcium ion elution and thus prevents inflammatory responses and cytotoxicity excited by the calcium ion in a tissue adjacent to a site where the artificial bone material is implanted.