| 摘要 |
The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. |
| 主权项 |
1. A compound of Formula Ib, or its tautomeric forms, stereoisomers including R and S isomers, or pharmaceutically acceptable salts thereof, wherein: ring A is phenyl; ring B is morphonilyl, attached to ring A through a nitrogen atom at any available position of ring A, ring B can further be fused to one or more aryl; R1, R2 and R4 are independently selected from —H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 alkoxyalkyl, C3-20 cycloalkyl, —CORa, —COORa, —CONRaRb, and —SO2Ra each of which may be optionally substituted at any available position by one or more substituents selected from but not limited to halogen, —ORa; R3 represents —(CH2)pZ; Z is selected from —H or —ORa; R5 is independently selected from —H, halogen; R6 is independently selected from —H or C1-12 alkyl; Q is O; Ra and Rb are same or different and can independently be selected from —H, C1-12 alkyl, C3-20 cycloalkyl, heterocyclyl, aryl, heteroaryl; m is 0, 1, 2, 3 or 4; r is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; s is 0, 1, 2, 3 or 4. |
