| 摘要 |
This invention relates to the use of imidizopyridine derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ. Suitably, the present invention relates to the use of imidizopyridines in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3Kβ selective imidizopyridine compounds for treating cancer. |
| 主权项 |
1. A compound of formula (I): wherein R1 is selected from H, —OH, and —C(O)OH; R2 is selected from H, and C1-3alkyl; and each of R6 and R7 is independently selected from C1-3alkyl, halogen, and —CF3, or R6 and R7 combine with the ring to which they are attached to form napththal; or a pharmaceutically acceptable salt thereof. |
