摘要 |
The present invention relates to compounds of formula (I):;
and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes. |
主权项 |
1. A compound of the formula I wherein: A is a 5-7 membered saturated heterocyclyl group containing one nitrogen and optionally one oxygen, wherein one carbon of said heterocyclyl group is optionally substituted with one or two groups selected from C1-3alkyl and oxo; R1 is C1-4 alkyl optionally substituted with a methoxy group; R2 is selected from H, F, Cl, C1-3alkyl, —CN, —OMe and —CF3; R3 is selected from H and —CH3; R4 is selected from H, F, —CH3 and —OMe; R5 is selected from H, Cl, —CH3, —CH2CH3, —CF3, F, and —OMe; R6 is bonded to the nitrogen on A and is selected from H, C1-6alkyl, —(CH2)nC3-6cycloalkyl, —C(O)C1-6alkyl, —(CH2)n heterocyclyl, —(CH2)n aryl —(CH2)n heteroaryl, —SO2aryl, SO2C1-6alkyl wherein said C1-6alkyl, —(CH2)n heterocyclyl, —(CH2)n cycloalkyl, —(CH2)n aryl and —(CH2)n heteroaryl are optionally substituted with one to four groups independently selected from C1-3alkyl, halogen, C1-3alkoxy, —CF3, —OH, oxo, —(CH2)1-3O(CH2)2-3OH, and —SO2CH3; R7 is selected from H, —CH3, —CH2CH3, —CF3, F, and —CN; n is 0, 1 or 2 or a salt thereof. |