发明名称 |
Methods and compositions for the treatment and diagnosis of haemorrhagic conversion |
摘要 |
The invention provides a method for predicting a hemorrhagic disorder in a patient consisting determining amine oxidase and, particularly, VAP-1 in a sample from said patient. The invention also provides pharmaceutical compositions comprising an inhibitor of amine oxidase and an antithrombotic agent as well as the use of an inhibitor of amine oxidase for treatment of hemorrhagic disorders. |
申请公布号 |
US8906642(B2) |
申请公布日期 |
2014.12.09 |
申请号 |
US200913062205 |
申请日期 |
2009.09.02 |
申请人 |
Universitat Autonoma de Barcelona |
发明人 |
Vilallonga Joan Montaner;Hernández-Guillamón Mar;López Mercedes Unzeta |
分类号 |
C12Q1/26;G01N33/573 |
主分类号 |
C12Q1/26 |
代理机构 |
Cooper & Dunham LLP |
代理人 |
Gershik Gary J.;Cooper & Dunham LLP |
主权项 |
1. A method of treating a patient for parenchymal hemorrhage in a patient who has suffered an ischemic stroke and has been treated with a thrombolytic agent comprising:
a) measuring the level of VAP-1 in a sample of blood, plasma or serum from said patient by immunoassay or enzymatic assay; b) comparing the measured level of VAP-1 to a reference control sample value, wherein a statistically significant elevation of VAP-1 is indicative of increased risk of suffering a parenchymal hemorrhage; and, c) treating said patient for parenchymal hemorrhage if there is a statistically significant elevation in the measured level of VAP-1. |
地址 |
Bellaterra-Barcelona ES |