Methods and systems for progressively treating and controlling oral periopathogens causing systemic inflammations

摘要

Methods and systems for treating and controlling oral periopathogens that have been found to be associated with systemic inflammation and/or disease in a periodontal pocket, inhibiting their entry into the host circulatory system, and decreasing the systemic effects. A bacterial community present in one or more oral treatment regions is determined. A periodontal medicament delivery tray is prepared for the patient with the delivery tray being configured with one or more application regions, each configured for applying a medicament to a different one of the oral treatment regions. The medicaments are applied to each oral treatment region, including placing each medicament into a different application region of the delivery tray. Each of the applied medicaments is applied as a function of a determined efficacy of the medicament against the bacterial community determined to be in the oral treatment region associated with the application region in which each medicament is applied.

主权项

1. A method of treating and controlling oral periopathogens, comprising:
performing an evaluation examination of a patient including evaluating two or more treatment regions of the patient on a common arch containing a plurality of teeth having potential periopathogens, each treatment region having at least one tooth on the common arch and determining a bacterial community having one more identified bacteria and a biofilm present in each treatment region; preparing a periodontal medicament delivery tray for the patient for two or more teeth of the common arch, the delivery tray having two or more medicament specific and differentiated application regions each including one or more tooth indentations, each application region being matched to a different one of the treatment regions and configured for applying at least one of two or more medicaments to the matched different one of the specific and differentiated treatment regions of the common arch, each application region being separate from another one of the different application regions to target medicament delivery therein, with each application region including each tooth of each matched different treatment region; selecting a particular medicament to be applied to each of the treatment regions from among a plurality of potential medicaments, selecting including at least one antimicrobial medicament as a function of the at least one antimicrobial medicament's capability penetrating the determined biofilm and inhibiting further growth or killing of at least one bacteria within the determined bacterial community as determined to be in each treatment region, wherein at least two of the particular selected medicaments for two different treatment regions include a different antimicrobial medicament; placing each selected particular medicament in a different one of the matched specific and different application regions of the delivery tray associated with a different one of the two or more particular treatment regions for which the medicament was selected; and applying the periodontal medicament delivery tray on the common arch and about the teeth of the common arch of the patient with each of the two more selected particular medicaments being applied to a separate and different treatment region during the applying.