Preparation method of 4-aminomethylbenzoic acid

摘要

The present invention relates to a preparation method of 4-aminomethylbenzoic acid comprising the following steps: preparing 4-carboxylbenzaldehyde or an alkyl ester thereof (methyl 4-formyl benzoate); reacting the 4-carboxylbenzaldehyde or an alkyl ester thereof (methyl 4-formyl benzoate) with hydroxyamine to oximate the same; and contact reducing 4-carboxylbenzaldehyde oxime or an alkyl ester oxime thereof obtained by the oximation, through hydrogen in a sodium hydroxide aqueous solution. Since methyl 4-hydroxyiminomethylbenzoate is reacted as a raw material in the presence of an alkali, hydrogen of a relatively low pressure can be used and a purification process is also simple, thereby enabling preparation of 4-aminomethylbenzoic acid with a low cost and high yield.

主权项

1. A method of preparing 4-aminomethylbenzoic acid, comprising:
preparing methyl 4-formylbenzoate; reacting the methyl 4-formylbenzoate with hydroxylamine, thus producing methyl 4-hydroxyiminomethylbenzoate; and subjecting the methyl 4-hydroxyiminomethylbenzoate to catalytic reduction using hydrogen in a sodium hydroxide aqueous solution, wherein the catalytic reduction is performed at a stirring rate of at least 1200 rpm.