| 发明名称 | C7-fluoro substituted tetracycline compounds | ||
| 摘要 | The present invention is directed to a compound represented by Structural Formula (A):; or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use. | ||
| 申请公布号 | US8906887(B2) | 申请公布日期 | 2014.12.09 |
| 申请号 | US200912462795 | 申请日期 | 2009.08.07 |
| 申请人 | Tetraphase Pharmaceuticals, Inc. | 发明人 | Zhou Jingye;Xiao Xiao-Yi;Plamondon Louis;Hunt Diana Katharine;Clark Roger B.;Zahler Robert B. |
| 分类号 | A61K31/65;C07C237/26;C07D233/61;C07D207/34;C07D295/088;C07D211/60;C07D257/04;C07D295/15;C07D209/94;C07D231/14;A61K45/06;C07D207/14;C07D333/34;C07C311/08;C07D231/56;C07C311/21;C07D207/10;C07D413/12;C07D213/81;C07D249/04;C07D261/20;C07D207/09;C07D239/42;C07D333/38;C07D277/56;C07D207/08;C07D231/12;C07D207/12;C07D213/82;C07D205/04;C07D295/26;C07D207/16;C07D261/18;C07D211/76;C07D213/74 | 主分类号 | A61K31/65 |
| 代理机构 | Hamilton, Brook, Smith & Reynolds, P.C. | 代理人 | Hamilton, Brook, Smith & Reynolds, P.C. |
| 主权项 | 1. A solid pharmaceutical composition comprising a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, wherein the compound is present in an amount effective to treat bacterial infections in a range from about 0.5 milligrams to about 500 milligrams. | ||
| 地址 | Watertown MA US | ||