Non-invasive characterization of human vasculature

摘要

Vascular conditions are detected non-invasively in the human body using a collection of information from small local regions of the vasculature. An array of accelerometers or other sensors are attached to the head or other points of interest of a patient and blood flow sounds are recorded. Vibration signatures of vessel structures such as branches, aneurysms, stenosis, etc. using random, periodic, band limited or transient analysis provides a library for further processing. The signature library is used to localize the origin of the recognized vascular feature, and the localized feature is presented to the physician in a clinically relevant manner.

主权项

1. A method for detecting, recording, analyzing, and storing data of cranial vasculature of a patient with or without a cranial vascular abnormality, at a region of interest, including the steps of:
(a) using an array of accelerometers engaged externally at a plurality of different positions against a patient's head, measuring acceleration and recording pressure wave/motion stimulation acceleration signal data from displacements of the skull at said plurality of positions on the skull, such displacements occurring from heartbeat-induced repeated pulsing of blood flow into the vasculature of the brain and resultant expansion and subsequent contraction of the blood vessels which moves the brain tissue due to such pulsing, the brain tissue movement causing resultant displacement of the skull at said plurality of positions on the skull, and (b) associating said signal data to characteristics of known signals of cranial vascular anomalies, in a computer, and finding any matches of said signal data to known signals of vascular anomalies, and further including (c) correlating signal data from multiple accelerometers of said array to determine a waveform signal common to the signal data from the multiple accelerometers and determining phase time differences among the signal data from the multiple accelerometers to thereby determine origins of a series of signal data collected by the multiple accelerometers from said displacements of the skull, thus localizing at least one signal from the signal data of the multiple accelerometers to define location of a structure of a vascular anomaly, and (d) storing results of the correlation and localizing steps as metadata in a database.