| 摘要 |
<p>The present invention is directed to a new class of lipids, more specifically ether-lipids having a polar headgroup, as well as vesicles comprising these lipids, methods of their preparation as well as their uses in medical applications, wherein the ether-lipids are represented by general formula (I) wherein Y represents O, N, S or a covalent bond; P1 represents H, an Y- protecting group or an Y-activating group or a spacer group; P2, P3 represent independently of each other H, an amino-protecting group or a spacer group, or P2 and P3 form together with the N to which they are bound a ring structure; L is a group of formula (a) wherein the dashed line represents the linkage to N; R1 represents H or a group of formula -(CH2)2-ORb1; R1 represents H or a group of formula - (CH2)2-ORb2, R2 represents H or a group of formula -CH2-ORc; R2 Represents H or a group of formula -ORd or -CH2-ORc,' R2 represents H or a group of formula -(CH2)2-ORe or -(CH2)3-ORe; Ra, Rb1, Rb2, Rc, Rd,Re represent independently of each other a saturated or unsaturated, straight or branched hydrocarbon chain, and m is 1, 2 or 3; with the proviso that at least one of R1, R1', R2, R2', R3 is not H.</p> |
