Una composicion farmaceutica para administracion sublingual que comprende una mezcla de a) microparticulas de alfentanilo, presentandose en las superficies de particulas vehiculo mas grandes, b) una base debil soluble en agua, y c) un compuesto acido debil en mezcla intima con las microparticulas de alfentanilo; su procedimiento de preparacion; y su uso para el tratamiento del dolor.

摘要

There is provided pharmaceutical compositions for the treatment of pain e.g. short-term pain, which compositions comprise a mixture comprising: (a) microparticles of alfentanil, or a pharmaceutically acceptable salt thereof, which microparticles are presented on the surfaces of larger carrier particles; (b) a water-soluble weak base; and (c) a compound which is a weak acid, which acid is presented in intimate mixture with the microparticles of alfentanil or salt thereof. The composition may further comprise a disintegrant. The acid is preferably citric acid.