| 摘要 |
PROBLEM TO BE SOLVED: To provide a novel medicinal application of a JAK inhibitor.SOLUTION: Provided is a therapeutic or preventive agent for skin disease selected from a group consisting of senile xerosis, asteatosis, eczema, and contact dermatitis, containing a JAK inhibitor as an active ingredient. The JAK inhibitor is found to increase an expression amount of filaggrin, loricrin, involucrin, and beta-defensin 3, which are skin barrier function-related proteins, to significantly promote NMF production in a Tape Stripping-treated mouse, and to significantly promote reduction of TEWL in a dry skin mouse model, that is, to improve a skin barrier function. The JAK inhibitor can be used as an active ingredient of a therapeutic or preventive agent for skin disease, such as senile xerosis, asteatosis, eczema, contact dermatitis, ichthyosis vulgaris, Netherton's syndrome, or type B peeling skin syndrome. |
