发明名称 |
METHOD FOR DETERMINING THE SURFACE CONCENTRATION OF CARBOXYL GROUPS ON A LENS |
摘要 |
The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens. |
申请公布号 |
US2014356965(A1) |
申请公布日期 |
2014.12.04 |
申请号 |
US201414289046 |
申请日期 |
2014.05.28 |
申请人 |
Novartis AG |
发明人 |
Qian Xinming;Chang Frank;Holland Troy Vernon;Qiu Yongxing;Shankar Venkat |
分类号 |
G01N33/44 |
主分类号 |
G01N33/44 |
代理机构 |
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代理人 |
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主权项 |
1. A method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens, comprising the steps of:
(a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens. |
地址 |
Basel CH |