发明名称 |
COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS |
摘要 |
A method of treating an ocular disorder in a subject includes administering to the subject a therapeutically effective amount of a primary amine compound of formula:;wherein R1 is an aliphatic and/or aromatic compound. |
申请公布号 |
US2014357611(A1) |
申请公布日期 |
2014.12.04 |
申请号 |
US201414460108 |
申请日期 |
2014.08.14 |
申请人 |
Case Western Reserve University |
发明人 |
Palczewski Krzysztof;Maeda Akiko;Golczak Marcin |
分类号 |
A61K31/549;A61K31/4152;A61K31/198;A61K31/428;A61K31/13;A61K31/4985;A61K31/407;A61K31/196;A61K31/197 |
主分类号 |
A61K31/549 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating an ocular disorder of a subject in need thereof, the method comprising:
administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound; the primary amine compound upon administration to the subject forming a reversible Schiff-base with the all-trans-retinal without adversely affecting normal retinoid cycle performance; the primary amine compound when administered to a Rdh8−/− Abca4−/− mouse increasing the optical coherence tomography score of the mouse to at least about 2.5 and increasing 11-cis-retinal amount at least about 30% in comparison to untreated control animal, wherein the primary amine compound is not a local anesthetic, which includes an aromatic amine, that demonstrates sodium channel blockade when administered to the subject. |
地址 |
Cleveland OH US |