COMPOSITION, THE NANO-EMULSION AND TRANSDERMAL PATCH, METHODS OF PREPARATION AND USE THEREOF FOR TREATING TRAUMATIC INJURIES

摘要

The present invention is a herbal composition and method of preparing thereof. The herbal composition comprising extracts of Carthami Flos (CF), Dipsaci Radix (DR), Notoginseng Rhizoma (NR) and Rhei Rhizoma (RR). The present invention also relates to an oil-in-water or water-in-oil type nano-emulsion and method of preparing thereof. The nano-emulsion comprises an aqueous phase, an organic phase and a surfactant, wherein said aqueous phase comprises hydrophilic extract of herbal materials and said organic phase comprises hydrophobic extract of said herbal materials. The present invention also relates to a transdermal patch comprises said nano-emulsion. The herbal composition of the present invention is useful in treating traumatic injuries, in particular bone injuries. The present nano-emulsion and patch thereof can promote skin absorption of active ingredients in herb, thereby increasing the herb's bioavailability and efficacy in therapy.

主权项

1. A herbal composition comprising hydrophilic extracts of Carthami Flos (CF), Dipsaci Radix (DR), Notoginseng Rhizoma (NR) and Rhei Rhizoma (RR) extracted by a hydrophilic solvent, hydrophobic extracts of Carthami Flos (CF), Dipsaci Radix (DR), Notoginseng Rhizoma (NR) and Rhei Rhizoma (RR) extracted by a hydrophobic solvent, and optionally a pharmaceutical acceptable carrier, wherein the herbal composition excludes extracts of Fructus Gardeniae (FG) and Sambucus Williamsii (SW).