| 主权项 |
1. A method of treating schizophrenia or a symptom of schizophrenia or a positive symptom of schizophrenia in a psychotic disease, comprising administering a pharmaceutical composition to a mammal in need of such treatment, wherein the pharmaceutical composition comprises a therapeutically effective amount of a compound of Formula 1:wherein
R1 is a group Ar1L2Ar2Alk-; Ar1 is a naphthyridynyl group optionally substituted with one or more -L3(Alk2)tL4(R4)u atoms or groups; L3 and L4 are each, independently, a covalent bond, —O—, —S—, —C(O)—, —C(O)O—, —OC(O)—, —C(S)—, —S(O)—, —S(O)2—, —N(R8)—, —CON(R8)—, —OC(O)N(R8)—, —CSN(R8)—, —N(R8)CO—, —N(R8)C(O)O—, —N(R8)CS—, —S(O)2N(R8)—, —N(R8)S(O)2—, —N(R8)O—, —ON(R8)—, —N(R8)N(R8)—, —N(R8)CON(R8)—, —N(R8)CSN(R8)—, or —N(R8)SO2N(R8)—; R8 is a hydrogen atom or a straight or branched C1-6alkyl group optionally substituted with one, two, or three substituents selected from halogen, hydroxy and C1-6alkoxy; t is zero or the integer 1; u is an integer 1, 2 or 3; Alk2 is an aliphatic or heteroaliphatic chain optionally substituted with one or more substituents selected from halogen, —OH, —CO2H, —CO2R9, —CONHR9, —CON(R9)2, —COR9, C1-6alkoxy, thiol, —S(O)R9, —S(O)2R9, C1-6 alkylthio, amino, —NHR9 and —N(R9)2; R9 is a straight or branched C1-6alkyl group optionally substituted with one, two, or three substituents selected from halogen, hydroxy and C1-6alkoxy; R4 is a hydrogen atom; a halogen atom; C1-6alkyl optionally substituted with one, two, or three substituents selected from halogen, hydroxy and C1-6alkoxy; C3-8cycloalkyl optionally substituted with one, two, or three substituents selected from halogen, hydroxy and C1-6alkoxy; —OR5; —SR5; —NR5R6; —NO2; —CN; —CO2R5; —SO3H; —SOR5; —SO2R5; —SO3R5; —OCO2R5; —CONR5R6; —OCONR5R6; —CSNR5R6; —COR5; —OCOR5; —N(R5)COR6; —N(R5)CSR6; —SO2N(R5)(R6); —N(R5)SO2R6; N(R5)CON(R6)(R7); —N(R5)CSN(R6)(R7); or —N(R5)SO2N(R6)(R7), provided that when t is zero and each of L3 and L4 is a covalent bond, then u is the integer 1 and R4 is other than a hydrogen atom; R5, R6, R7, and R11 are each, independently, a hydrogen atom or a C1-6alkyl or C3-8cycloalkyl group, wherein each of said alkyl and cycloalkyl groups is optionally substituted with one, two, or three substituents selected from halogen, hydroxy and C1-6alkoxy; L2 is an N(R8) group; Ar2 is an arylene or heteroarylene group optionally substituted with one or more -L3(Alk2)tL4(R4)u atoms or groups; Alk is a chain —CH2—CH(R)—, —CH═C(R)—, or R is a carboxylic acid (—CO2H), a carboxylic acid ester (—CO2Alk7), a carboxylic acid amide (—CONR5R6), a tetrazole, phosphonic acid, phosphinic acid, sulphonic acid, sulphinic acid, boronic acid, or an acylsulphonamide group; Alk7 is a straight or branched C1-8alkyl group, C2-8alkenyl group, C2-8alkynyl group, C3-8cycloalkyl group, C3-8heterocycloalkyl group, C3-8cycloalkylC1-8alkyl group, C3-8heterocycloalkylC1-8alkyl group, C1-6alkyloxyC1-6alkyl group, hydroxyC1-6alkyl group, C1-6alkylthioC1-6alkyl group, C1-6alkylsulfinylC1-6alkyl group, C1-6alkylsulfonylC1-6alkyl group, C3-8cycloalkyloxyC1-6alkyl group, C3-8cycloalkylthioC1-6alkyl group, C3-8cycloalkylsulfinylC1-6alkyl group, C3-8cycloalkylsulfonylC1-6alkyl group, C1-6alkyloxycarbonylC1-6alkyl group, C1-6alkyloxycarbonylC1-6alkenyl group, C1-6alkyloxycarbonyloxyC1-6alkyl group, C1-6alkyloxycarbonyloxyC1-6alkenyl group, C3-8cycloalkyloxycarbonyloxyC1-6alkyl group, N-di-C1-8alkylaminoC1-8alkyl group, N—C6-12aryl-N—C1-6alkylaminoC1-6alkyl group, N-di-C1-8alkyl-carbamoylC1-8alkyl group, C6-12arylC1-6alkyl group, heteroC6-10arylC1-6alkyl group, C6-12aryl group, a C6-12aryloxyC1-8alkyl group, a C6-12arylthioC1-8alkyl group, a C6-12arylsulfinylC1-8alkyl group, a C6-12arylsulfonylC1-8alkyl group, C1-8alkanoyloxyC1-8alkyl group, C4-8imidoC1-8alkyl group, a C6-12aroyloxyC1-8alkyl group, or a triglyceride, optionally substituted with one or more R13a groups; R13a is a halogen atom, or an amino (—NH2), NHR14, —N(R14)2, nitro, cyano, amidino, hydroxyl (—OH), —OR14, formyl, carboxyl (—CO2H), esterified carboxyl, thiol (—SH), —SR14, SC(═NH)NH2, —COR14, CSR14, —SO3H, —SOR14, —SO2R14, —SO3R14, —SO2NH2, —SO2NHR14, —SO2N(R14)2, —CONH2, —CSNH2, —CONHR14, —CSNHR14, —CON(R14)2, —CSN(R14)2, —N(R11)SO2R14, —N(SO2R14)2, —NH(R11)SO2NH2, —N(R11)SO2NHR14, —N(R11)SO2N(R14)2, —N(R11)COR14, —N(R11)CONH2, —N(R11)CONHR14, —N(R11)CON(R14)2, N(R11)CSNH2, —N(R11)CSNHR114, N(R11)CSN(R14)2, —N(R11)CSR14, —N(R11)C(O)OR14, —SO2NHet1, —CONHet1, —CSNHet1, —N(R11)SO2NHet1, —N(R11)CONHet1, —N(R11)CSNHet1, —SO2N(R11)Het2, -Het2, —CON(R11)Het2, —CSN(R11)Het2, —N(R11)CON(R11)Het2, —N(R11)CSN Het2, aryl or heteroaryl group; R14 is an -Alk6(R13a)m, aryl, or heteroaryl group; Alk6 is a straight or branched C1-6alkylene, C2-6alkenylene or C2-6alkynylene chain, optionally interrupted by one, two or three —O— or —S— atoms or —S(O)p or —N(R15)— groups; m is zero or the integer 1, 2 or 3; p is an integer 1 or 2; R15 is a hydrogen atom or C1-6alkyl group; Het1 is a C5-7cyclicamino group optionally containing one or more —O— or —S— atoms or —N(R11)—, —C(O)—, —C(S)—, —S(O) or —S(O)2 groups and optionally substituted with one or more substituents selected from halogen, —OH, —CO2H, —CO2R9, CONHR9, —CON(R9)2, —COR9, C1-6alkoxy, thiol, —S(O)R9, —S(O)2R9, C1-6alkylthio, amino, —NHR9 and —N(R9)2; Het2 is a monocyclic C5-7carbocyclic group optionally containing one or more —O— or —S— atoms or —N(R11)—, —C(O)— or —C(S)— groups and optionally substituted with one or more substituents selected from halogen, —OH, —CO2H, —CO2R9, —CONHR9, —CON(R9)2, —COR9, C1-6alkoxy, thiol, —S(O)R9, —S(O)2R9, C1-6alkylthio, amino, —NHR9 and —N(R9)2; X is an —O— or —S— atom or an —N(R2)— group; R2 is a hydrogen atom or a C1-6alkyl group; V is an oxygen (O) or sulfur (S) atom; Rz is an atom or group -L1(Alk1)n(R3)v; L1 is a covalent bond, an —O—, —S—, or —Se— atom, or a —C(O)—, —C(O)O—, —OC(O)—, —C(S)—, —S(O)—, —S(O)2—, —N(R8)—, —CON(R8)—, —OC(O)N(R8)—, —CSN(R8)—, —N(R8)CO—, —N(R8)C(O)O—, —N(R8)CS—, S(O)2N(R8)—, —N(R8)S(O)2—, —N(R8)O—, —ON(R8)—, —N(R8)N(R8)—, —N(R8)CON(R8)—, —N(R8)CSN(R8)—, or —N(R8)SO2N(R8)— group; Alk1 is an aliphatic or heteroaliphatic chain optionally substituted with one or more substituents selected from halogen, —OH, —CO2H, —CO2R9, —CONHR9, —CON(R9)2, —COR9, C1-6alkoxy, thiol, —S(O)R9, —S(O)2R9, C1-6alkylthio amino, —NHR9 and —N(R9)2; R3 is a hydrogen or halogen atom or a group selected from —OR3a, —SR3a, —CN and a C3-10cycloalkyl; C3-10cycloalkenyl; C3-10heterocycloalkyl or C3-10heterocycloalkenyl containing 1, 2, 3 or 4 heteroatoms or heteroatom-containing groups L5, where L5 is defined as for L3; aromatic or heteroaromatic group optionally substituted with one or more substituents selected from halogen, C1-6alkyl, haloC1-6alkyl, —C(OH)(CF3)2, C1-6alkoxy, haloC1-6alkoxy, thiol, C1-6alkylthio, -(Alk4)gR10, —CN, —CO2R11, —NO2, —CON(R11)2, —CSN(R11)2, —COR11, —CSN(R11)2, —N(R11)COR11, —N(R11)CSR11, —SO2N(R11)2, N(R11)SO2R11, —N(R11)CON(R11)2, —N(R11)CSN(R11), N(R11)SO2N(R11)2, and phenyl optionally substituted with one, two or three R13 groups; R13 is —R13a or -Alk6(R13a)m; Alk4 is a straight or branched C1-3alkylene chain; g is zero or an integer 1; R10 is —OH, —SH, or —N(R11)2; R3a is a hydrogen atom or a straight or branched C1-6alkyl group or C3-8cycloalkyl group, wherein each of said alkyl and cycloalkyl groups is optionally substituted with one, two, or three substituents selected from halogen, hydroxy, and C1-6alkoxy; n is zero or the integer 1; v is the integer 1, 2 or 3; provided that when n is zero and L1 is a covalent bond, v is the integer 1; RX and RY, together with the carbon atom to which they are attached, are joined together to form a spiro linked cyclopentyl, cyclohexyl, cycloheptyl, or tetrahydropyranyl group optionally substituted with one or more substituents selected from halogen, C1-6alkyl, haloC1-6alkyl, —C(OH)(CF3)2, C1-6alkoxy, haloC1-6alkoxy, thiol, C1-6alkylthio, -(Alk4)gR10, —CN, —CO2R11, —NO2, —CON(R11)2, —CSN(R11)2, —COR11, —CSN(R11)2, —N(R11)COR11, —N(R11)CSR11, —SO2N(R11)2, —N(R11)SO2R11, —N(R11)CON(R11)2, —N(R11)CSN(R11), N(R11)SO2N(R11)2, and phenyl optionally substituted with one, two or three R13 groups;or a salt, solvate, hydrate or N-oxide thereof. |
