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1. A compound of the formula (I) in which A represents nitrogen or CR5,
whereR5 represents hydrogen, deuterium, chlorine, iodine, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, cyclopropyl, cyclobutyl, phenyl or 5- or 6-membered heteroaryl which is attached via carbon,
in which (C1-C6)-alkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, phenyl and 5- or 6-membered heteroaryl which is attached via carbon may each be substituted by 1 to 3 substituents selected independently of one another from the group comprising cyano, fluorine, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, (C1-C4)-alkoxycarbonyl, hydroxy, hydroxycarbonyl, cyclopropyl, cyclobutyl and —(C═O)—NR21R22,in which(C1-C6)-alkyl may be substituted by an —NR13R14 group,in whichR13 represents hydrogen, methyl or ethyl,
in whichethyl may be substituted by 1 to 3 fluorine substituents,R14 represents hydrogen, (C1-C4)-alkyl, —(C═O)—R15 or —S(O)2—R16,
in which(C1-C4)-alkyl may be substituted by 1 to 3 fluorine substituents,and in whichR15 represents (C1-C4)-alkyl or (C3-C5)-cycloalkyl,R16 represents (C1-C4)-alkyl or (C3-C5)-cycloalkyl,orR13 and R14 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle,
in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of trifluoromethyl, (C1-C4)-alkyl, hydroxy and oxo,and in whichR21 represents hydrogen or (C1-C4)-alkyl,R22 represents hydrogen or (C1-C4)-alkyl,
in which (C1-C4)-alkyl for its part may in each case be substituted by hydroxy or fluorine,orR21 and R22 together with the atom to which they are attached form a 4- to 7-membered heterocycle, L represents a #1-CR6AR6B—(CR7AR7B)m-#2 group
where#1 is the point of attachment to the carbonyl group,#2 is the point of attachment to the pyrimidine or triazine ring,m represents a number 0, 1 or 2,R6A represents hydrogen, fluorine, (C1-C4)-alkyl, hydroxy or amino,
in which (C1-C4)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C1-C4)-alkoxy, hydroxycarbonyl, (C1-C4)-alkoxycarbonyl and amino,R6B represents hydrogen, fluorine, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C2-C6)-alkenyl, cyano, (C3-C7)-cycloalkyl, difluoromethoxy, trifluoromethoxy or a group of the formula -M-R12,
in which (C1-C6)-alkyl may be substituted by 1 to 3 substituents selected independently of one another from the group consisting of (C1-C4)-alkoxy, fluorine, cyano, trifluoromethyl, (C3-C7)-cycloalkyl, difluoromethoxy and trifluoromethoxy,in which (C1-C4)-alkoxy may be substituted by phenyl,and in whichM represents a bond or (C1-C4)-alkanediyl,R12 represents —(C═O)r—OR8, —(C═O)r—NR8R9, —C(═S)—NR8R9, —NR8—(C═O)—R11, —NR8—(C═O)—OR11, —NR8—(C═O)—NR9R10, —NR8—SO2—NR9R10, —NR8—SO2—R11, —S(O)s—R11, —SO2—NR8R9, 4- to 7-membered heterocyclyl, phenyl, benzyl or 5- or 6-membered heteroaryl,
in whichr represents the number 0 or 1,s represents the number 0, 1 or 2,R8, R9 and R10 independently of one another each represent hydrogen, (C1-C6)-alkyl, (C3-C8)-cycloalkyl, 4- to 7-membered heterocyclyl, phenyl or 5- or 6-membered heteroaryl,orR8 and R9 together with the atom(s) to which they are respectively attached form a 4- to 7-membered heterocycle, in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of cyano, trifluoromethyl, (C1-C6)-alkyl, hydroxy, oxo, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkoxycarbonyl, amino, mono-(C1-C6)-alkylamino and di-(C1-C6)-alkylamino,orR9 and R10 together with the atom(s) to which they are respectively attached form a 4- to 7-membered heterocycle, in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of cyano, trifluoromethyl, (C1-C6)-alkyl, hydroxy, oxo, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkoxycarbonyl, amino, mono-(C1-C6)-alkylamino and di-(C1-C6)-alkylamino,R11 represents (C1-C6)-alkyl or (C3-C7)-cycloalkyl,orR8 and R11 together with the atom(s) to which they are respectively attached form a 4- to 7-membered heterocycle, in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of cyano, trifluoromethyl, (C1-C6)-alkyl, hydroxy, oxo, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkoxycarbonyl, amino, mono-(C1-C6)-alkylamino and di-(C1-C6)-alkylamino,andin which 4- to 7-membered heterocyclyl, phenyl and 5- or 6-membered heteroaryl for their part may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, hydroxy, oxo, thioxo and (C1-C4)-alkoxy,andin which the aforementioned (C1-C4)-alkyl, (C1-C6)-alkyl, (C3-C8)-cycloalkyl and 4- to 7-membered heterocyclyl groups, unless stated otherwise, may each independently of one another additionally be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, hydroxy, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, hydroxycarbonyl, (C1-C4)-alkoxycarbonyl, amino, phenyl, 4- to 7-membered heterocyclyl and 5- or 6-membered heteroaryl,orR6A and R6B together with the carbon atom to which they are attached form a (C2-C4)-alkenyl group, an oxo group, a 3- to 6-membered carbocycle or a 4- to 7-membered heterocycle,
in which the 3- to 6-membered carbocycle and the 4- to 7-membered heterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C1-C4)-alkyl,R7A represents hydrogen, fluorine, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl or hydroxy,R7B represents hydrogen, fluorine, (C1-C4)-alkyl or trifluoromethyl, R1 represents hydrogen, fluorine, cyano, (C1-C4)-alkyl, (C1-C4)-alkoxy, trifluoromethyl, difluoromethyl, (C3-C6)-cycloalkyl or halogen, R2 represents benzyl, 3,3,3-trifluoroprop-1-yl, 4,4,4-trifluorobut-1-yl or 3,3,4,4,4-pentafluorobut-1-yl,
where benzyl is substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, chlorine, (C1-C4)-alkyl, cyclopropyl and (C1-C4)-alkoxy, R3 represents hydrogen, cyano, (C1-C4)-alkyl, (C1-C4)-alkoxy, trifluoromethyl, difluoromethyl or (C3-C6)-cycloalkyl, R4 represents hydrogen, cyano, (C1-C4)-alkyl, (C1-C4)-alkoxy, trifluoromethyl, difluoromethyl or (C3-C6)-cycloalkyl, or an N-oxides, salt or salt of an N-oxide thereof. |
