发明名称 |
ANTI-CSPG4 FUSIONS WITH INTERFERON FOR THE TREATMENT OF MALIGNANCY |
摘要 |
In various embodiments chimeric moieties (constructs) are provided that show significant efficacy against cancers. In certain embodiments the constructs comprise a targeting moiety that specifically binds CSPG4 attached to an interferon or to a mutant interferon. In certain embodiments, the constructs comprise anti-CSPG4 antibody attached to an interferon alpha (IFN-α) or to a mutant interferon alpha or to an interferon beta (IFN-&bgr;) or to a nutant interferon beta, or to an interferon gamma (IFN-γ) or to a mutant interferon gamma. |
申请公布号 |
WO2014194100(A1) |
申请公布日期 |
2014.12.04 |
申请号 |
WO2014US40036 |
申请日期 |
2014.05.29 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;TIMMERMAN, JOHN M. |
发明人 |
TIMMERMAN, JOHN M.;MORRISON, SHERIE L.;TRINH, KHAM M. |
分类号 |
C07K16/46;A61K39/395;A61P35/00;C12N15/09 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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