| 发明名称 |
HUMAN GROWTH HORMONE RECEPTOR ANTAGONIST ANTIBODIES AND METHODS OF USE THEREOF |
| 摘要 |
The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation. |
| 申请公布号 |
US2014356359(A1) |
申请公布日期 |
2014.12.04 |
| 申请号 |
US201214367483 |
申请日期 |
2012.12.10 |
| 申请人 |
RINAT NEUROSCIENCE CORP. |
发明人 |
Siebel Sara Iva;Pascua Edward Derrick;Lin Chia-Yang;Chaparro Riggers Javier Fernando |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An isolated GHR antagonist antibody that specifically binds to human and cynomolgus monkey growth hormone receptor (GHR) and, when administered to a subject, lowers a level of insulin-like growth factor-1 (IGF-1) in blood of said subject. |
| 地址 |
South San Francisco CA US |
