发明名称 |
Anti -transglutaminase 2 antibodies |
摘要 |
The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer. |
申请公布号 |
AU2013265025(A1) |
申请公布日期 |
2014.12.04 |
申请号 |
AU20130265025 |
申请日期 |
2013.05.24 |
申请人 |
MEDICAL RESEARCH COUNCIL TECHNOLOGY |
发明人 |
JOHNSON, TIM;WATSON, PHIL;MATTHEWS, DAVID;BROWN, ALEX |
分类号 |
C07K16/40 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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