发明名称 SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH DIETARY WEIGHT LOSS
摘要 The present invention relates to genetic polymorphisms associated with obesity and obesity-related phenotypes and their use in predicting if an individual looses weight during a dietary weight loss intervention program.
申请公布号 US2014356869(A1) 申请公布日期 2014.12.04
申请号 US201214361084 申请日期 2012.11.22
申请人 DSM IP ASSETS B.V. 发明人 Sorensen Thorklid
分类号 C12Q1/68 主分类号 C12Q1/68
代理机构 代理人
主权项 1. A method for assessing whether an individual will loose more weight when consuming a low fat/high carbohydrate diet or when consuming a high fat/low carbohydrate diet, the method comprising the step of determining the genotype of the single nucleotide polymorphism rs987237 in the TFAP2B gene, wherein: (i) the presence of two A allelic forms of the SNP rs987237 is indicative of an increased likelihood that the individual looses more weight on a low fat/high carbohydrate diet compared to a high fat/low carbohydrate diet and, (ii) the presence of AG or GG allelic forms of the SNP rs987237 is indicative of an increased likelihood that the individual looses more weight on a high fat/low carbohydrate diet compared to a low fat/high carbohydrate diet.
地址 The Heerlen NL