Antibody-Conjugated Double-Emulsion Nanocapsule and Preparation Methods Thereof

摘要

An antibody-conjugated double-emulsion nanocapsule is provided. A linking group is introduced on the surface of a double-emulsion nanocapsule, which is composed of an oily shell enclosing an aqueous core, to link the double-emulsion nanocapsule with an antibody.

主权项

1. An antibody-conjugated double-emulsion nanocapsule, comprising:
an aqueous core; an oily shell enclosing the aqueous core, wherein a composition of the oily shell comprises a polymer and a plurality of hydrophobic magnetic nanoparticles but does not comprise other polymers and other surfactants, and wherein the polymer is a linking polyvinyl alcohol or a combination of polyvinyl alcohol (PVA) and a linking polymer, and the linking polyvinyl alcohol and the linking polymer have a linking group; and at least an antibody chemically bonded to the linking group via a coupling agent, wherein a diameter of the antibody-conjugated double-emulsion nanocapsule is about 50 nm to about 400 nm.