发明名称 |
CANCER VACCINES AND METHODS OF TREATMENT USING THE SAME |
摘要 |
Disclosed are vaccine compositions comprising one or more nucleic acid encoding one or more amino acid sequence(s) selected from the group consisting of amino acid sequences of tyrosinase (Tyr), tyrosinase-related protein 1 (TYRP1 ), tyrosinase-related protein 2 (TYRP2), melanoma-associated antigen 4 protein (MAGEA4), growth hormone release hormone (GHRH), MART-1/melan-A antigen, cancer testis antigen NY-ESO-1, cancer testis antigen NY-ESO-2, preferentially expressed antigen in melanoma (PRAME), Wilms' tumor 1 (WT1), and human telomerase reverse transcriptase (hTERT). The vaccine compositions can further comprise a nucleic acid encoding one or more other antigens including prostate specific antigen (PSA). Further disclosed are methods of preventing or treating cancer in a subject in need comprising administering to the subject a vaccine composition comprising a particular number of cancer antigens for treating or preventing a particular cancer. |
申请公布号 |
WO2014144885(A3) |
申请公布日期 |
2014.12.04 |
申请号 |
WO2014US29479 |
申请日期 |
2014.03.14 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;WEINER, DAVID;MUTHUMANI, KARUPPIAH;WALTERS, JEWELL;YAN, JIAN |
发明人 |
WEINER, DAVID;MUTHUMANI, KARUPPIAH;WALTERS, JEWELL;YAN, JIAN |
分类号 |
A61K48/00;A61K38/00;C07H21/04;C07K14/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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地址 |
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