发明名称 |
COMBINATION THERAPIES FOR CANCER |
摘要 |
A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and a PD-1 antagonist; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf and/or immune modulation through PD-1 is beneficial, e.g., cancer. |
申请公布号 |
WO2014193898(A1) |
申请公布日期 |
2014.12.04 |
申请号 |
WO2014US39686 |
申请日期 |
2014.05.28 |
申请人 |
MERCK SHARP & DOHME CORP.;GLAXOSMITHKLINE LLC;HOOS, AXEL;ORFORD, KEITH, W.;CHUN, PATRICK;SRIRAM, VENKATARAMAN;PINHEIRO, ELAINE, M.;EBBINGHAUS, SCOT, W. |
发明人 |
HOOS, AXEL;ORFORD, KEITH, W.;CHUN, PATRICK;SRIRAM, VENKATARAMAN;PINHEIRO, ELAINE, M.;EBBINGHAUS, SCOT, W. |
分类号 |
A61K31/506;A61K31/519;A61P35/00;C07D413/12 |
主分类号 |
A61K31/506 |
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