NOVEL NANOCARRIER DELIVERED CANCER CHEMOTHERAPEUTIC AGENTS

摘要

Compositions and methods for treating cancer in a subject are described herein. The composition includes modified nucleobases and nucleosides that are converted in the cell to nucleotides that are incorporated into growing DNA and result in termination of DNA elongation. The nucleobases and nucleotides are incorporated with a drug delivery system (DDS). The DDS includes &bgr;-cyclodextrin. The nucleobases and nucleotides are conjugated to the &bgr;-cyclodextrin by an acid labile linker that releases the nucleobases and nucleotides in the acidic environment of cancer cells. The DDS may also include a targeting ligand that targets the DDS/ nucleobase or nucleotide conjugate to cancer cells. The DDS/ nucleobase or nucleotide conjugate may self form into nanoparticles and may be administered to a subject with cancer in an amount effective to treat said cancer.