发明名称 RNAi Inhibition of Serum Amyloid A For Treatment of Glaucoma
摘要 RNA interference is provided for inhibition of serum amyloid A mRNA expression in glaucomas involving SAA expression.
申请公布号 US2014357692(A1) 申请公布日期 2014.12.04
申请号 US201414180145 申请日期 2014.02.13
申请人 Novartis AG 发明人 Clark Abbot F.;Wang Wan-Heng;McNatt Loretta Graves
分类号 C12N15/113 主分类号 C12N15/113
代理机构 代理人
主权项 1. A composition comprising an effective amount of interfering RNA comprising a sense nucleotide sequence and an antisense nucleotide sequence, wherein the antisense sequence comprises(SEQ ID NO: 37)CUUUGCCACUCCUGCCCCA,(SEQ ID NO: 38)UCGGAAGUGAUUGGGGUCU,(SEQ ID NO: 39)UUUGUCUGAGCCGAUGUAA,(SEQ ID NO: 40)AACCAGGCCCGUGAGAAGC,(SEQ ID NO: 41)CUGAGCCGAUGUAAUUGGC,(SEQ ID NO: 69)GCCACUCCUGCCCCAUUUA,(SEQ ID NO: 42)CCCCCGAGCAUGGAAGUAU,(SEQ ID NO: 43)CUCUGGCAUUGCUGAUCAC,(SEQ ID NO: 44)GCCUGUGAGUCUCUGGAUA,(SEQ ID NO: 45)GCCACUCCUGCCCCAUUUA,(SEQ ID NO: 46)GCCAGCAGGUCGGAAGUGA,(SEQ ID NO: 47)AGUCUCUGGAUAUUCUCUC,(SEQ ID NO: 48)UUUAUUGGCAGCCUGAUCG,(SEQ ID NO: 49)UUGCUGAUCACUUCUGCGG,(SEQ ID NO: 50)CUGGAUAUUCUCUCUGGCA,(SEQ ID NO: 51)UCUGCCACUCCUGCCCCAU,(SEQ ID NO: 52)AACCCCUUGGAGAGCCUCC,(SEQ ID NO: 53)UGCCCAUGUCCCCAACCCC,(SEQ ID NO: 54)AUAGAGAUAUCUGUUUGAA,(SEQ ID NO: 55)CGAGCAUAGAGAUAUCUGU,(SEQ ID NO: 56)CUUUGGGCAGCAUCAUAGU,(SEQ ID NO: 57)AGACACCCCCAGGUCCUCU,(SEQ ID NO: 58)CCUGGAACGGCUGAUGAGU,(SEQ ID NO: 59)CCAAAUAAAUAGUAGUCUA,(SEQ ID NO: 60)UCCAAUACAGUGCUGCUGU,(SEQ ID NO: 61)CUCAGCUUUCUCGUUGGAC,(SEQ ID NO: 62)CCAUUCCUCAGCUUUCUCG,(SEQ ID NO: 63)CCGGCCCCAUUCCUCAGCU,(SEQ ID NO: 64)CUUUGCCACUCCGGCCCCA,or(SEQ ID NO: 65)UCUGAAGCGGUCGGGGUCU.
地址 Basel CH