| 发明名称 |
IL-17 RECEPTOR A ANTIGEN BINDING PROTEINS |
| 摘要 |
The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein. |
| 申请公布号 |
US2014356355(A1) |
申请公布日期 |
2014.12.04 |
| 申请号 |
US201414304472 |
申请日期 |
2014.06.13 |
| 申请人 |
Amgen Inc. |
发明人 |
Tocker Joel E.;Peschon Jacques J.;Fitzpatrick David;Smothers James F.;Mehlin Christopher;Lim Ai Ching |
| 分类号 |
C07K16/28;A61K45/06;A61K39/395 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody, comprising a human monoclonal antibody or IL-17 Receptor A binding fragment thereof that specifically binds IL-17 Receptor A and inhibits IL-17A from binding and activating said receptor. |
| 地址 |
Thousand Oaks CA US |
