NOVEL MONASCUSPURPURONES, PREPARATION PROCESS THEREOF, AND USES OF THE MONASCUSPURPURONES

摘要

The present invention relates to a novel monascuspurpurone compound of formula (I):;;or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses to of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPARγ and/or C/EBPα, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.

主权项

1. A method for promoting adipocyte differentiation in a subject, which comprises administering to said subject an effective amount of the compound of formula (I) or a pharmaceutically acceptable derivative thereof,
wherein the compound of formula (I) is wherein R1 and R2 are independently selected from the group consisting of alkyl, alkenyl, and carbonyl and R3 is alkyl.