METHODS FOR REDUCING REMNANT CHOLESTEROL AND OTHER LIPOPROTEIN FRACTIONS BY ADMINISTERING AN INHIBITOR OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN-9 (PCSK9)

摘要

The present invention provides methods for reducing various lipoprotein fractions in the serum of patients. The methods of the invention include reducing serum remnant cholesterol, and/or the serum concentration of one or more LDL-C subfractions in a patient. The methods of the present invention comprise selecting a patient who exhibits elevated serum lipoproteins, and administering to the patient a pharmaceutical composition comprising a PCSK9 inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody such as the exemplary antibody referred to herein as mAb316P.

主权项

1. A method for reducing in a patient the serum concentration of one or more of: (a) remnant cholesterol; (b) VLDL; (c) VLDL1+2-C; (d) VLDL3-C; and/or (e) IDL-C; the method comprising selecting a patient with elevated serum remnant cholesterol, VLDL, VLDL1+2-C, VLDL3-C; and/or IDL-C, and administering to the patient a pharmaceutical composition comprising a PCSK9 inhibitor.