| 发明名称 |
AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS |
| 摘要 |
The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like. |
| 申请公布号 |
US2014356316(A1) |
申请公布日期 |
2014.12.04 |
| 申请号 |
US201113581148 |
申请日期 |
2011.02.24 |
| 申请人 |
Connor Eric;Biyani Kalpesh;Hecker Scott;Lees Inez;Huynh Grace;Salaymeh Faleh;Zhang Hongmin;Bergbreiter David;Mansky Paul;Mu YongQi;Cope Michael James;Goka Elizabeth;Lee Angela;Madsen Deidre;Shao Jun;Zhang Xinnan |
发明人 |
Connor Eric;Biyani Kalpesh;Hecker Scott;Lees Inez;Huynh Grace;Salaymeh Faleh;Zhang Hongmin;Bergbreiter David;Mansky Paul;Mu YongQi;Cope Michael James;Goka Elizabeth;Lee Angela;Madsen Deidre;Shao Jun;Zhang Xinnan |
| 分类号 |
A61K31/785;C08G73/02 |
主分类号 |
A61K31/785 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An amine polymer comprising repeat units derived from polymerization of an amine monomer having six, seven or eight possible reaction sites and a crosslinking monomer having two or three possible reaction sites, wherein the molar ratio of the amine monomer to the crosslinking monomer is in the range of from 1:3 to about 1:1.1, and the amine polymer has a binding affinity for bile acids of at least 0.46 mmol/g when measured using an in vitro A assay. |
| 地址 |
Los Gatos CA US |
