METHOD FOR PREPARING CRYSTAL FORM F OF ERLOTINIB HCL

摘要

The present invention relates to a new method for preparing crystal form F of erlotinib HCl. The method comprises adding an erlotinib free alkali in a C4 alcohol into hydrogen chloride dissolved in an organic solvent, and crystallizing the resulting erlotinib HCl. The method of the invention has the advantages of being suitable for large-scale preparation and having reproducibility. Furthermore, the method of the present invention also comprises the conversion of the crystal form F of erlotinib HCl into other crystal forms.