NOVEL 2'-C-METHYL NUCLEOSIDE DERIVATIVE COMPOUNDS

摘要

Compositions and methods relating to 2′-C-methyl nucleoside 5′-monophosphate derivative compounds are provided. In some embodiments, the novel compounds are useful to treat viral infections. In particular, 2′-C-methyl nucleoside 5′-monophosphate derivative compounds, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of viral infection are described.

主权项

1. A compound selected from the group consisting of the compounds of Formula I, and the compounds of Formula II: wherein:
R is an optionally substituted phenyl or an optionally substituted pyridyl;R1 is selected from the group consisting of hydrogen, a C1-C10 alkyl, C1-C10 alkenyl, and a C1-C10 heteroalkyl;R2 is selected from the group consisting of OR5, acyloxy, and F;R3 is a C1-C6 alkyl or a C1-C6 heteroalkyl, or R2 and R3 can be linked to form a —O— bond;R4 is selected from the group consisting of OR5 and acyloxy, or R3 and R4 can be linked to form a —O— bond; andR5 is selected from the group consisting of hydrogen, a C1-C10 alkyl, a C1-C10 haloalkyl, and a C1-C10 heteroalkyl, and the stereoisomers and the pharmaceutically acceptable salts thereof.