发明名称 |
Ring constrained analogs as Arginase inhibitors |
摘要 |
<p>The inventive boronic acid analogs are potent inhibitors of Arginase I and II activity. These compounds are candidate therapeutics for treating a disease or disorder associated with an imbalance in the activity or concentration of cellular arginase I and arginase II enzymes. The invention also provides pharmaceutical compositions of the inventive compounds and methods for using the compositions for therapy.</p> |
申请公布号 |
AU2013249790(A1) |
申请公布日期 |
2014.12.04 |
申请号 |
AU20130249790 |
申请日期 |
2013.03.13 |
申请人 |
MARS, INCORPORATED |
发明人 |
VAN ZANDT, MICHAEL;JAGDMANN JR., GUNNAR ERIK |
分类号 |
C07F5/02;A61K31/00;A61K49/00;A61P35/00 |
主分类号 |
C07F5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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