FORMULATIONS OF LYCOPENE IN COMBINATION WITH BISPHOSPHONATES BONE RESORPTION INHIBITORS

摘要

The present invention provides a pharmaceutical formulation suitable for filling softgel capsules comprising: (a) from about 1% to about 90% by weight of a bisphosphonic acid or a pharmaceutically acceptable salt; (b) from 1% to about 99% by weight of lycopene and (c) from about 40% to about 80% by weight of a liquid carrier comprising 50% to 80% by weight polyethylene glycol; 5% to 15% by weight of glycerin; and 5% to 20% by weight water. The invention also describes a method for preparing alendronate or its pharmaceutical acceptable salts in encapsulated therapeutic dosage form in combination with lycopene.

主权项

1. A pharmaceutical composition comprising:
(a) effective amounts of a bone resorption inhibitor; and (b) effective amounts of lycopene.