发明名称 |
OXYNTOMODULIN ANALOGS |
摘要 |
Peptide analogs of oxyntomodulin (OXM, glucagon-37), which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to act as a dual GLP-1/glucagon receptor (GCGR) agonist are described. The peptide analogs are useful for treatment of metabolic disorders such as diabetes and obesity. |
申请公布号 |
PT2398483(E) |
申请公布日期 |
2014.12.04 |
申请号 |
PT20090840594T |
申请日期 |
2009.12.18 |
申请人 |
MERCK SHARP & DOHME CORP.;INDIANA UNIVERSITY RESEARCH&TECHNOLOGY CORPORATION;ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. |
发明人 |
PAUL E. CARRINGTON;GEORGE J. EIERMANN;DONALD J. MARSH;JOSEPH. M. METZGER;ALESSANDRO POCAI;RANABIR SINHA ROY;ELISABETTA BIANCHI;PAOLO INGALLINELLA;ANTONELLO PESSI;ALESSIA SANTOPRETE;ELENA CAPITO;RICHARD DIMARCHI;BRIAN WARD |
分类号 |
A61K38/00;C07K14/575;C07K14/605 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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