| 主权项 |
1. A process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): wherein, R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, optionally substituted straight, branched or cyclic C1-20 alkyl, optionally substituted straight, branched or cyclic C1-20 alkoxy, optionally substituted C6-20 aryl, optionally substituted C6-20 aryloxy, —OH, —CN, —NR20R21, —COOH, COOR20, —CONH2, —CONR20R21 and —CF3, wherein the substituents are selected from the group consisting of one or more straight, branched or cyclic C1-20 alkyl, straight, branched or cyclic C1-20 alkoxy, C6-20 aryl, C6-20 aryloxy, —OH, —CN, —NR30R31, —COOR30, —CONR30R31 and —CF3; R1 and R2, R2 and R3, R3 and R4 or R4 and R5 together form an aromatic ring composed of 6 to 10 carbon atoms which is optionally substituted with one or more straight, branched or cyclic C1-20 alkyl, straight, branched or cyclic C1-20 alkoxy, C6-20 aryl, C6-20 aryloxy, —OH, —CN, —NR20R21, —COOR20, —CONR20R21 and —CF3; R6, R7, R8 and R9 are each independently selected from the group consisting of hydrogen, optionally substituted straight, branched or cyclic C1-20 alkyl, optionally substituted straight, branched or cyclic C1-20 alkoxy, optionally substituted C6-20 aryl and optionally substituted C6-20 aryloxy wherein the substituents are selected from the group consisting of one or more straight, branched or cyclic C1-20 alkyl, straight, branched or cyclic C1-20 alkoxy, C6-20 aryl, C6-20 aryloxy, —OH, —CN, —NR20R21, —COOR20, —CONR20R21 and —CF3, or R6 and R7 together with the carbon atom to which they are bound and/or R8 and R9 together with the carbon atom to which they are bound form an optionally substituted C3-20 cycloalkyl or an optionally substituted C2-20 cycloalkoxy, wherein the substituents are selected from the group consisting of one or more straight, branched or cyclic C1-20 alkyl, straight, branched or cyclic C1-20 alkoxy, C6-20 aryl, C6-20 aryloxy, —OH, —CN, —NR20R21, —COOR20, —CONR20R21 and —CF3, or one of R6 and R7 and one of R8 and R9 together form an optionally substituted C5-10 cycloalkyl or an optionally substituted C5-10 cycloalkoxy, wherein the substituents are independently selected from the group consisting of one or more straight, branched or cyclic C1-20 alkyl, straight, branched or cyclic C1-20 alkoxy, C6-20 aryl, C6-20 aryloxy, —OH, —CN, —NR20R21, —COOR20, —CONR20R21 and —CF3, or R10 is an optionally substituted straight, branched or cyclic C1-10 alkyl, an optionally substituted C6-10 aryl or —NR11R12 wherein the substituents are selected from the group consisting of one or more straight, branched or cyclic C1-10 alkyl, straight, branched or cyclic C1-10 alkoxy, C6-10 aryl, C6-10 aryloxy, -Hal, —OH, —CN, —NR20R21, —COOR20, —CONR20R21 and —CF3; R11 and R12 are independently selected from the group consisting of hydrogen, optionally substituted straight, branched or cyclic C1-10 alkyl and optionally substituted C6-10 aryl, wherein the substituents are selected from the group consisting of one or more straight, branched or cyclic C1-10 alkyl groups, straight, branched or cyclic C1-10 alkoxy, C6-10 aryl, C6-10 aryloxy, —OH, —CN, —NR20R21, —COOR20, —CONR20R21 and —CF3, or R11 and R12 together with the nitrogen atom to which they are bound form an optionally substituted C2-10 cycloalkyl-amino group wherein the substituents are selected from the group consisting of one or more straight, branched or cyclic C1-10 alkyl, straight, branched or cyclic C1-10 alkoxy, C6-10 aryl, C6-10 aryloxy, —OH, —CN, —NR20R21, —COOR20, —CONR20R21 and —CF3; R20 and R21 are independently selected from the group consisting of hydrogen, optionally substituted straight, branched or cyclic C1-20 alkyl, optionally substituted straight, branched or cyclic C1-20 alkoxy, optionally substituted C6-20 aryl, optionally substituted C6-20 aryloxy, —OH, —CN, —NR30R31, —COOR30, —CONR30R31 and —CF3, wherein the substituents are selected from the group consisting of one or more straight, branched or cyclic C1-20 alkyl, straight, branched or cyclic C1-20 alkoxy, C6-20 aryl, C6-20 aryloxy, —OH, —CN and —CF3; R30 and R31 are independently selected from the group consisting of hydrogen, optionally substituted straight, branched or cyclic C1-20 alkyl, optionally substituted straight, branched or cyclic C1-20 alkoxy, optionally substituted C6-20 aryl, optionally substituted C6-20 aryloxy, —OH, —CN and —CF3, wherein the substituents are selected from the group consisting of one or more straight, branched or cyclic C1-20 alkyl, straight, branched or cyclic C1-20 alkoxy, C6-20 aryl, C6-20 aryloxy, —OH, —CN and —CF3; A is an optionally substituted straight- or branched-chain C2-5 alkyl wherein the substituents are selected from the group consisting of one or more straight, branched or cyclic C1-10 alkyl, straight, branched or cyclic C1-10 alkoxy, C6-10 aryl and C6-10 aryloxy, or A is a group of formula (II): wherein p is an integer selected from 1, 2, 3 or 4; each R40 is independently selected from the group consisting of straight, branched or cyclic C1-20 alkyl, straight, branched or cyclic C1-20 alkoxy, C6-20aryl, C6-20 aryloxy, —OH, —CN or —CF3; q and r are independently integers selected from 0, 1, 2 or 3 wherein q+r=1, 2 or 3; each R41 is independently selected from the group consisting of hydrogen, straight, branched or cyclic C1-20 alkyl, straight, branched or cyclic C1-20 alkoxy, C6-20 aryl, C6-20 aryloxy, —OH, —CN and —CF3; and Hal is a halogen. |
