CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS

摘要

The invention provides a branched linker compound with reactive moieties for forming covalent bonds with multiple cytotoxic agents (drugs) and/or a cell-binding agent (CBA); a cytotoxic compound comprising a branched linker moiety with a reactive group for forming a CBA-drug conjugates; a modified cell-binding agent comprising a branched linker moiety with a reactive group for forming a CBA-drug conjugates; and conjugates so formed. Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose.