发明名称 |
NEW BIS-INDOLE ALKALOIDS AS ANTICANCER DRUGS |
摘要 |
<p>The field of this invention relates to novel cyclopropyl derivatives of the general formula (I) representing pharmaceutically applicable Vinca Rosea type alkaloid compounds, particularly having a cytostatic effect. The invention also is concerned processes for preparing these new alkaloids and their pharmacological compositions and the use of these compounds in treatment of cancer. R stands for a methyl or a formyl group, R1 stands for a methoxy or an amino group, R2 represents a hydroxy or acetoxy group, R3 stands for a hydrogen atom or a hydroxy group, R4 represents a hydrogen atom or R3 and R4 together represent a double bond, R5 and R6 represent hydrogen or fluorine atoms n = 1 or 2.</p> |
申请公布号 |
WO2014191964(A1) |
申请公布日期 |
2014.12.04 |
申请号 |
WO2014IB61836 |
申请日期 |
2014.05.30 |
申请人 |
RICHTER GEDEON NYRT. |
发明人 |
SZÁNTAY, CSABA;HAZAI, LÁSZLÓ;KALAUS, GYÖRGY;KEGLEVICH, PÉTER |
分类号 |
C07D519/04;A61K31/437;A61P35/00 |
主分类号 |
C07D519/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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