发明名称 |
COMPOSITIONS AND METHODS OF MODULATING AN IMMUNE RESPONSE |
摘要 |
<p>Compositions for and methods of stimulating a MHC I mediated immune response comprising stimulating MHC I endolysosomal cross presentation in dendritic cells. Stimulation MHC I endolysosomal cross presentation may comprise over-expression CD74 in dendritic cells and/or targeting antigens to the MHC I endolysosomal cross presentation pathway. Fusion proteins comprising an antigen or fragment thereof and a CD74 endolysosomal targeting sequence are also provided.</p> |
申请公布号 |
EP2807193(A1) |
申请公布日期 |
2014.12.03 |
申请号 |
EP20120866895 |
申请日期 |
2012.07.31 |
申请人 |
BIOMMUNE TECHNOLOGIES INC. |
发明人 |
JEFFERIES, WILFRED;BASHA, GENC;OMILUSIK, KYLA;CHAVEZ-STEENBOCK, ANA |
分类号 |
C07K19/00;A61K38/01;A61K39/00;A61K39/385;A61P37/04;C07K14/705;C07K17/04;C12N5/07;C12N5/0784;C12Q1/00 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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