发明名称 |
A RECONSTITUTED HIGH DENSITY LIPOPROTEIN FORMULATION AND PRODUCTION METHOD THEREOF |
摘要 |
A reconstituted high density lipoprotein formulation having relatively low toxicity comprises an apolipoprotein such as ApoAI or fragment thereof, a lipid and a detergent at a level which is about 5-50% of that which would normally cause liver toxicity upon administration to a human. The lipid is optimally phosphatidylcholine at about 30-50 g/L and the molar ratio of apolipoprotein:lipid is optimally in the range 1:40 to 1:75. The formulation is useful for treating diseases or conditions such as cardiovascular disease, hypercholesterolaemia and hypocholesterolaemia inclusive of acute coronary syndrome (ACS), atherosclerosis and myocardial infarction. |
申请公布号 |
EP2588113(A4) |
申请公布日期 |
2014.12.03 |
申请号 |
EP20110799979 |
申请日期 |
2011.06.30 |
申请人 |
CSL LIMITED |
发明人 |
WRIGHT, SAMUEL;IMBODEN, MARTIN;BOLLI, REINHARD;WAELCHLI, MARCEL |
分类号 |
A61K31/56;A61K31/685;A61P3/06;A61P9/10 |
主分类号 |
A61K31/56 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|