| 发明名称 | Interferon alpha mutant and its polyethylene glycol derivative | ||
| 摘要 | IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in vivo half-life are also provided, wherein a polyethylene glycol moiety is covalently bound to the free Cys residue of an IFN-alpha mutant. The preparation methods of PEG derivatives of IFN-alpha mutants and medical compositions comprising the derivatives are also provided. The test results showed that the IFN-alpha mutants of the present invention are ready to prepare and have high activity; their polyethylene glycol derivatives have extended lifetime in the body and low clearance rate. | ||
| 申请公布号 | US8901277(B2) | 申请公布日期 | 2014.12.02 |
| 申请号 | US201213431226 | 申请日期 | 2012.03.27 |
| 申请人 | Beijing Tri-Prime Genetic Engineering Co., Ltd;Beijing Bio-Tech Development Co., Ltd. | 发明人 | Liu Jinyi;Niu Xiaoxia;Zhou Minyi;Yang Yi;Sun Jianbo;Cheng Yongqing |
| 分类号 | C07K14/52;C12N15/00;A61K38/21;C07K1/00;C12P21/04;C07K14/56;A61K47/48;A61K38/00 | 主分类号 | C07K14/52 |
| 代理机构 | Scully, Scott, Murphy & Presser, P.C. | 代理人 | Scully, Scott, Murphy & Presser, P.C. |
| 主权项 | 1. An isolated interferon-α mutant protein comprising the amino acid sequence of SEQ ID NO: 2, 3 or 4. | ||
| 地址 | Beijing CN | ||