pH sensor integration to single use bioreactor/mixer

摘要

A pH sensing bioreaction system is provided. The system includes a bioreaction container having a plastic wall and a pH sensor attached to the plastic wall. The pH sensor includes a sensor body having a flange that is sealingly attached to the plastic wall. The sensor body has a reference electrolyte therein and a first sensing element disposed in the reference electrolyte. The first sensing element is configured to contact both the reference electrolyte and a sample solution inside the bioreaction container. A second sensing element is positionable into an interior of the bioreaction container. The pH sensor has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container, and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container.

主权项

1. A pH sensing bioreaction system comprising:
a bioreaction container having a plastic wall; a pH sensor including:
a sensor body mounted substantially external to the bioreaction container and having a flange sealingly attached to the plastic wall;a first sensing element being configured to contact a sample solution inside the bioreaction container when the pH sensor is in a service configuration;a second sensing element being positionable into an interior of the bioreaction container; andwherein the pH sensor has a plunger axially movable within the sensor body, the plunger having a first axial position in which at least one sensing element is isolated from the interior of the bioreaction container, and a second axial position in which the first and second sensing elements are fluidically coupled to the interior of the bioreaction container.