发明名称 Method for the cultivation of microorganisms of the genus thraustochytriales by using an optimized low salt medium
摘要 The invention relates to an optimized method for cultivating microorganisms of the genus Thraustochytriales, according to which the microorganisms are cultivated in a low salt medium without adding sodium salts and chloride salts, the total salt content being less than 3.5 g/L (corresponding to less than 10 percent of sea water salt content), whereupon the PUFAs are isolated from the microorganisms and/or the medium. The invention especially relates to novel optimized media having a substantially reduced total salt content, above all a particularly reduced NaCl content. The production of PUFAs can be substantially improved and significantly simplified by using a novel combination of different salts as a media composition in which the overall weight ratios of ions do not exceed 1.75 g/L. Furthermore, said medium preferably contains no added sodium salt and chloride salt at all, which helps prevent environmental damages caused by wastewaters containing salt.
申请公布号 US8900831(B2) 申请公布日期 2014.12.02
申请号 US200410578968 申请日期 2004.11.10
申请人 发明人 Rüsing Matthias;Luy Markus
分类号 C12P7/64;C12N1/00 主分类号 C12P7/64
代理机构 代理人
主权项 1. A method for cultivating microorganisms of the order Thraustochytriales, wherein the microorganisms are cultivated in a fermentation medium characterized in that the sum of the weight fractions of sodium and chloride ions is less than 1.75 g/L and that the total salt content of the fermentation medium is less than 3.5 g/L, and wherein during cultivation the microorganisms bring forth a production of more than 10 wt % DHA per dry biomass; and characterized in that the microorganism is selected from the group consisting of Ulkenia sp. SAM 2179 and Schizochytrium sp. SR 21.
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