Polymer films for medical device coating

摘要

A method for depositing a coating comprising a polymer and impermeable dispersed solid on a substrate, comprising the following steps: discharging at least one impermeable dispersed solid in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or impermeable dispersed solid particles onto said substrate, wherein an electrical potential is maintained between the substrate and the impermeable dispersed solid and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not disrupt the activity and/or function of the substrate. A similar method is provided for depositing a coating comprising a hydrophobic polymer and a water-vapor-trapping material on a substrate.

主权项

1. A method of preparing a coated biomedical implant comprising:
providing a biomedical implant; depositing on said biomedical implant a first layer comprising a hydrophobic polymer; depositing on said biomedical implant a second layer comprising an impermeable dispersed solid, wherein the impermeable dispersed solid and the hydrophobic polymer are discharged separately through a first and/or second orifice and wherein the impermeable solid is discharged through the first or second orifice as a dry powder and deposited in dry powder form, and sintering the first and second layers under conditions that do not substantially disrupt the activity and/or function of the biomedical implant thereby forming a coating, wherein the coating substantially seals the biomedical implant; and wherein the coating is substantially impermeable to a gas; the coating is substantially impermeable to a fluid; and the coating is substantially impervious to a biological material.