Diethylstilbestrol dosage form and methods of treatment using thereof

摘要

Oral dosage forms as a biodegradable, water soluble film for delivering pharmaceutically active agents, particularly diethylstilbestrol and pharmaceutically acceptable salts thereof to patients through insertion into the mouth of patient and methods for administering pharmaceutically active agents to patients by insertion into the mouth to provide selective uptake of said agents through the mucosa and thus avoiding the gastrointestinal tract.

主权项

1. A method for treating prostate or breast cancer in a patient comprising
administering the oral unit dosage form as a water soluble matrix to the oral mucosal membranes of the mouth of a patient, which matrix contains, dispersed therein, a pharmaceutical agent selected from the group consisting of diethylstilbestrol and pharmaceutically acceptable salts of diethylstilbestrol, said pharmaceutical agent being present in said matrix in an amount effective for treating said prostate or breast cancer, said matrix composed of a one or more sucrose fatty acid esters having an HLB of about 8 to 16, wherein the matrix is a film whereby the pharmaceutical agent is absorbed through the mucosal membrane providing high blood levels of diethylstilbestrol and low levels of fibrinogen.