| 发明名称 | Methods of applying coating materials for solid medicines | ||
| 摘要 | A method improves stability of drugs in a solid pharmaceutical formulation against oxygen and water vapor by coating the solid pharmaceutical formulation with a coating material including a high hydrogen-bonding resin and a swelling clay. | ||
| 申请公布号 | US8900606(B2) | 申请公布日期 | 2014.12.02 |
| 申请号 | US201313796006 | 申请日期 | 2013.03.12 |
| 申请人 | Toray Industries, Inc. | 发明人 | Hayashi Yuki;Fujisaki Yuki;Yoshii Ryoji |
| 分类号 | A61K9/30;A61K9/42;A61K47/02;A61K9/28;A61K47/32 | 主分类号 | A61K9/30 |
| 代理机构 | DLA Piper LLP (US) | 代理人 | DLA Piper LLP (US) |
| 主权项 | 1. A method of improving stability of drugs in a solid pharmaceutical formulation against oxygen and water vapor comprising coating the solid pharmaceutical formulation with a coating material including a high hydrogen-bonding resin and a swelling clay and a sugar alcohol derivative surfactant, wherein an amount of the swelling clay in the coating material is 38 wt % to 60 wt % and a mass ratio of said polyvinyl alcohol and said swelling clay is 4:6 to 6:4, and wherein said sugar alcohol derivative surfactant is at least one selected from a group consisting of sorbitan monolaurate, sorbitan monopalmitate, sorbitan monooleate and sucrose stearate, and which said coating material forms a coating film in which laminated structures of said swelling clay are oriented planarly and dispersed in a network fashion. | ||
| 地址 | JP | ||