Substituted imidazo[1,5-A]quinoxalin-4-ones are useful for preventing or treating storage dysfunction, voiding dysfunction and bladder/urethral diseases

摘要

Substituted imidazo[1,5-a]quinoxalin-4-one compounds of formula (I) described herein exhibit PDE9-inhibitory action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like.

主权项

1. A compound selected from the group consisting of
(+)-7-[(5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-1-yl)carbonyl]-8-methyl-1-(tetrahydrofuran-3-yl)imidazo[1,5-a]quinoxalin-4(5H)-one, (+)-7-[(5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-1-yl)carbonyl]-8-(methoxymethyl)-1-(tetrahydrofuran-3-yl)imidazo[1,5-a]quinoxalin-4(5H)-one, (+)-8-(methoxymethyl)-7-[(5-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)carbonyl]-1-(tetrahydrofuran-3-yl)imidazo[1,5-a]quinoxalin-4(5H)-one, (+)-7-[(5-bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)carbonyl]-8-methyl-1-(tetrahydrofuran-3-yl)imidazo[1,5-a]quinoxalin-4(5H)-one, (+)-7-[(5-bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)carbonyl]-8-(methoxymethyl)-1-(tetrahydrofuran-3-yl)imidazo[1,5-a]quinoxalin-4(5H)-one; and (+)-7-[(5,6-difluoro-2,3-dihydro-1H-indol-1-yl)carbonyl]-8-methyl-1-(tetrahydrofuran-3-yl)imidazo[1,5-a]quinoxalin-4(5H)-one; or a pharmaceutically acceptable salt of said compound.