Calcium carbonate granulation

摘要

Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.

主权项

1. A method of making a high density calcium carbonate granulation for compression into a swallowable dietary supplement tablet comprising mixing a USP or food grade calcium carbonate powder having a packed density of 1.1 to 1.5 g/cm3 with a binding agent and water; and drying the resultant mixture in a fluidized bed to a water content of less than about 1% by weight, thereby resulting in a calcium carbonate granulation that is highly compactable and has a tap density between about 0.9 g/cm3 and about 2.0 g/cm3.