Liquid and low melting coatings for stents

摘要

Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms.

主权项

1. A method of coating a stent comprising:
providing a stent; providing a coating composition comprising an HMG-CoA reductase inhibitor in an amount of about 1 to 50 wt. %, and a polymeric biodegradable carrier component comprising a polymer selected from polycaprolactone, ethylene-vinyl acetate polymer, and a two-part silicone rubber; expanding the stent to an increased diameter; and applying the coating composition to the stent, wherein the HMG-CoA reductase inhibitor is released from the stent at a rate of >20 μg/ml per day.